9: Chemoselectivity - Chemistry LibreTexts
2022年9月13日 · Chemoselectivity is a term that describes the ability of a reagent or intermediate to react with one group or atom in a molecule in preference to another group or atom present in the same molecule.
Chemoselectivity: The Mother of Invention in Total Synthesis
2009年1月30日 · IUPAC defines chemoselectivity as “the preferential reaction of a chemical reagent with one of two or more different functional groups”, a definition that describes in rather understated terms the single greatest obstacle to complex molecule synthesis.
Chemoselectivity - Wikipedia
Chemoselectivity is the preferential reaction of a chemical reagent with one of two or more different functional groups. [1] In a chemoselective system, a reagent in the presence of an aldehyde and an ester would mostly target the aldehyde, even …
Regioselectivity vs. Stereoselectivity vs. Chemoselectivity
2023年11月21日 · Chemoselectivity. Chemoselectivity is when a reaction occurs on a single functional group in the presence of others. In other words, the reaction selects for one atom or group of atoms even in...
Stereoselective and Stereospecific Reactions - Master Organic Chemistry
2010年7月2日 · We can classify the different types of selectivity in organic chemistry into several important categories. Chemoselective reactions are selective for one functional group over another – for example, a reaction that selectively reacts with alkynes in the presence of alkenes.
Chemoselectivity preferential reactivity of one functional group (FG) over another - Chemoselective reduction of C=C over C=O: O H 2, Pd/C O - Chemoselective reduction of C=O over C=C: O NaBH 4 OH O + O NaBH 4, CeCl 3 OH only - Epoxidation: OH OH OH + MCPBA O O (2 : 1) OH OH O VO(acac) 2, tBuOOH exclusively
In this section, we will study the orientation (or regio-selectivity) and reactivity (chemo-selectivity) of addition to carbon-carbon multiple bonds. The structural orientation will not affect the final product if either the regent or the alkene is symmetrical in nature.
6: Chemoselectivity - Chemistry LibreTexts
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Chemoselectivity - an overview | ScienceDirect Topics
Chemoselectivity is the selective reactivity of a functional group in the presence of others. Protecting groups can be used instead of chemoselectivity but with the disadvantage of having to perform two additional synthesis steps (protection and deprotection).
Chapter 24 — chemoselectivity Regioselectivity vs. chemoselectivity vs. stereoselectivity Carbonyls as electrophiles Salmefamol synthesis Reagent control of selectivity: chemoselective carbonyl reductions More reductions Oxidizing alcohols Summary of protecting groups