Endothelial responses to shear stress in atherosclerosis: a ... - Nature
2019年7月31日 · In hypercholesterolaemic mice, deployment in the carotid artery of a constrictive cuff that generates spatial and temporal oscillation of the shear stress field results in the development of ...
Flow-induced reprogramming of endothelial cells in …
2023年5月24日 · Implanting a constrictive cuff (white bracket) on the RCA shown in the magnetic resonance imaging angiogram (MRA) exposes endothelial cells to low-magnitude, unidirectional, laminar shear...
TWIST1 Integrates Endothelial Responses to Flow in Vascular …
2016年5月31日 · This was achieved using a constrictive cuff that causes tapering of the lumen to generate high shear stress at the stenosis, low shear stress upstream, and low/oscillatory shear stress downstream. 6,30 Cuff placement for 14 days led to enhanced expression of GATA4 and TWIST1 at the low shear stress site , which is consistent with our in vitro data.
Venoconstrictive thigh cuffs (VTC) are a mechanical countermeasure capable of attenuating the spaceflight induced headward fluid shift, and thus may be a viable spaceflight associated neuro-ocular syndrome (SANS) countermeasure. Crewmembers can use VTC to mitigate the headward fluid shift to aid in adapting to spaceflight. However, data are
Veno-constrictive thigh cuffs (VTC; Braslets) provided to Soyuz crewmembers alleviate symptoms of the headward fluid shift during the first week of spaceflight and have been documented to reduce internal jugular vein (IJV) distension during weightlessness.7 Application of VTCs designed collaboratively by NASA Johnson Space Center Cardiovascular ...
Flow-induced reprogramming of endothelial cells in atherosclerosis
Implanting a constrictive cuff (white bracket) on the RCA shown in the magnetic resonance imaging angiogram (MRA) exposes endothelial cells to low-magnitude, unidirectional, laminar shear stress (ULS) in the proximal region of the cast, high-magnitude ULS within the cuff and low-magnitude oscillatory shear stress (OSS) in the distal region of ...
Daily use of veno-constrictive thigh cuffs during 30 days of strict …
2024年5月21日 · In addition, veno-constrictive thigh cuffs (VTC) can sequester blood volume in the legs. The purpose of this study was to determine whether 6 hours of daily VTC use following cycling exercise (Ex+VTC) could reverse the headward fluid …
Effects of Venoconstrictive Thigh Cuffs on Dry Immersion
2021年7月14日 · The main objectives of the present study were 2-fold: (1) to assess the neuro-ophthalmological impact during 5 days of DI and (2) to determine the effects of venoconstrictive thigh cuffs (VTC), used as a countermeasure to limit headward fluid shift, on DI-induced ophthalmological adaptations.
DI-5-CUFFS: Venoconstrictive Thigh Cuffs Limit Body Fluid …
2020年5月5日 · Venoconstrictive thigh cuffs are used by cosmonauts to ameliorate symptoms associated with cephalad fluid shift. A ground simulation of microgravity, using the dry immersion (DI) model, was performed to assess the effects of thigh cuffs on body fluid changes and dynamics, as well as on cardiovascular deconditioning.
Ultrasound Biomicroscopy for Longitudinal Studies of Carotid …
2012年1月5日 · In the present study, we have employed UBM for in vivo determination of carotid plaque length and percent stenosis, and have documented plaque progression over time in ApoE−/− mice fitted with either a constrictive cast or cuff. Additionally, using PW-Doppler, we have identified two velocity parameters that accurately predict plaque formation.
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