Continuous and Discontinuous Epitopes - Virus Infection
2022年12月20日 · A discontinuous epitope is a type of immunological epitope (an antigenic determinant) composed of multiple noncontiguous amino acid residues within a protein or polypeptide. Discontinuous epitopes are commonly found on large proteins and typically require several different antibody molecules to recognize the same epitope.
Epitope - an overview | ScienceDirect Topics
In one, the continuous epitope is a linear stretch of amino acids that is distinguished from the discontinuous epitope, which is formed from a group of spatially adjacent surface residues brought together by the folding of the polypeptide chain or from the juxtaposition of residues from two or more separate peptide chains.
Epitope - an overview | ScienceDirect Topics
By the same token, antibodies raised against denatured proteins or synthetic peptide antigens often recognize ‘continuous (sequential) epitopes’ and cannot recognize the corresponding proteins in their native conformations.
A generic approach to evaluate how B-cell epitopes are surface …
2010年12月15日 · The B-cell epitopes are classified into two categories: Continuous epitopes are composed of contiguous amino acids along the primary sequence, whereas discontinuous epitopes combine several shorter segments scattered along the sequence and brought together in spatial proximity when the protein is folded.
SVMTriP: a tool to predict linear antigenic epitopes
A continuous (also called linear) epitope is a consecutive fragment from the protein sequence, and a discontinuous epitope is composed of several fragments scattered along the protein sequence, which form the antigen-binding interface.
Epitope - an overview | ScienceDirect Topics
An epitope is called sequential or continuous if it can be represented by a series of contiguous residues of a polypeptide chain. An antibody is said to recognize a sequential epitope if it reacts with a short, flexible peptide or with the denatured, unfolded polypeptide chain.
PEPOP 2.0: new approaches to mimic non-continuous epitopes
2019年7月11日 · PEPOP 2.0 can generate series of peptide sequences that can replace continuous or discontinuous epitopes in their interaction with their cognate antibody. We have developed an improved version of PEPOP (PEPOP 2.0) dedicated to answer to experimentalists’ need for a tool able to handle proteins and to turn them into peptides.
Continuous versus discontinuous epitopes. This figure …
It was noted that researchers classify epitopes as either continuous or discontinuous (Figure 2), but many so-called discontinuous epitopes consist of stretches of several consecutive amino acids...
Continuous epitope - Medical Dictionary
Looking for online definition of continuous epitope in the Medical Dictionary? continuous epitope explanation free. What is continuous epitope? Meaning of continuous epitope medical term.
Analysis and prediction of protective continuous B-cell epitopes …
2008年1月7日 · We have investigated the integration of B-cell epitope prediction with the variability of antigen and the conservation of patterns for post-translational modification (PTM) prediction to improve over state of the art in the field. In particular the application of machine-learning methods shows promising results.