Cyclooxygenases: structural and functional insights - PMC
Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 are the …
Cyclooxygenase - Wikipedia
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, EC 1.14.99.1) that is responsible for biosynthesis …
Cyclooxygenase enzymes: catalysis and inhibition - ScienceDirect
2001年12月1日 · Cyclooxygenase (COX) enzymes catalyze the conversion of arachidonic acid (AA) to prostaglandin H 2 (PGH 2), the common biosynthetic precursor to prostaglandins and …
COX reactions | Pathway - PubChem
Biological pathway information for COX reactions from Reactome.
Cyclooxygenases: structural and functional insights
2008年10月23日 · Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 …
Structural and Chemical Biology of the Interaction of …
2020年7月1日 · Biosynthesis of PGs and TXA 2 is initiated by the bifunctional cyclooxygenases (COXs). These enzymes catalyze the bis-dioxygenation of AA to form the hydroperoxy …
Cyclooxygenase - an overview | ScienceDirect Topics
Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of biological mediators termed prostanoids, consisting of prostaglandin PGD2, PGE 2, PGF 2α, prostacyclin PGI 2, and …
The cyclooxygenases | Genome Biology | Full Text - BioMed Central
2004年8月27日 · Cyclooxygenases (COXs) catalyze the rate-limiting step in the production of prostaglandins, bioactive compounds involved in processes such as fever and sensitivity to …
Structural insights into the stereochemistry of the cyclooxygenase reaction
2000年5月4日 · Cyclooxygenase enzymes catalyse two sequential reactions in spatially distinct, but mechanistically coupled active sites 8, 9, 10, 11. The initial cyclooxygenase reaction …
Pharmacological analysis of cyclooxygenase-1 in inflammation
The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and …