Cyclase - Wikipedia
A cyclase is an enzyme, almost always a lyase, that catalyzes a chemical reaction to form a cyclic compound. Important cyclase enzymes include:
A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions …
2023年1月23日 · Here we report that PloI4, a β-barrel-fold protein homologous to the exo-selective 4 + 2 cyclase that functions in the biosynthesis of pyrroindomycins, catalyses competitive 2 + 2 and 4 + 2 ...
Structure and function of adenylyl cyclases, key enzymes in …
2020年8月1日 · Adenylyl cyclases (ACs) are the enzymes that generate cAMP, and thus the key components of the cAMP signaling and regulation pathways. In this review we provide a brief general overview of the field, focusing on the recent breakthroughs in our understanding of the structure and function of the ACs as the key enzymes in cellular signaling.
Cyclase - an overview | ScienceDirect Topics
Adenylate cyclase is a membrane-bound enzyme which occupies a central role in mediating the effects of a number of hormones on their target tissues (Sutherland et al., 1968). In the “two-messenger concept of hormone action” proposed by Sutherland, the hormone is thought to bind to a specific site on the superficial cell surface ( Pastan et ...
cyclase - 百度百科
cyclase，英语单词，主要用作名词，作名词时译为“环化酶”。 [1] nucleotide cyclase 核苷酸环化酶. Terpene cyclase 环化酶. cyclase activity 环化酶. adcnylyl cyclase 腺苷酸环化酶. Guanylate Cyclase [生化] 鸟苷酸环化酶 ; 鸟酸环酶 ; 酸环化酶 ; 环化酶. adenyl cyclase 腺苷酸环化酶 ; 化酉每 ; 组织腺苷酸环化酶 ; 激动腺苷酸环化酶. adenylaty cyclase 腺苷酸环化酶. adenyly cyclase 激活腺苷酸环化酶 ; 腺苷酸环化酶 ; 腺苷酰环化酶 [1]
Structural and Chemical Biology of Terpenoid Cyclases
2017年8月25日 · Terpenoid cyclases catalyze the most complex chemical reactions in biology, in that more than half of the substrate carbon atoms undergo changes in bonding and hybridization during a single enzyme-catalyzed cyclization reaction.
Discovery and evolution of [4 + 2] cyclases - ScienceDirect
2024年8月1日 · In this review, we present a comprehensive overview of recent advancements in characterizing [4 + 2] cyclases with regard to their catalytic mechanism and stereoselectivity. We particularly focus on insights gained from enzyme co–crystal structures, cofactors, as well as the effects of glycosylation.
Discovery, structure, and mechanism of a class II sesquiterpene cyclase …
Terpene cyclases (TCs), the extraordinary enzymes that create the structural diversity seen in terpene natural products, are traditionally divided into two classes. Although the structural and mechanistic features in class I TCs are well-known, the corresponding details in class II counterparts have not been fully characterized.
Class II terpene cyclases: structures, mechanisms, and engineering ...
2023年12月18日 · Terpene cyclases (TCs) catalyze some of the most complicated reactions in nature and are responsible for creating the skeletons of more than 95 000 terpenoid natural products. The canonical TCs are divided into two classes according to their structures, functions, and mechanisms.
Adenylyl Cyclase - Colorado State University
Adenylyl cyclase is the enzyme that synthesizes cyclic adenosine monophosphate or cyclic AMP from adenosine triphosphate (ATP). Cyclic AMP functions as a second messenger to relay extracellular signals to intracellular effectors, particularly protein kinase A .
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