DNA methylation - Wikipedia
DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription.
DNA Methylation and Its Basic Function
2012年7月11日 · DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factor(s) to DNA.
The Role of Methylation in Gene Expression - Nature
Today, researchers know that DNA methylation occurs at the cytosine bases of eukaryotic DNA, which are converted to 5-methylcytosine by DNA methyltransferase (DNMT) enzymes.
DNA methylation and its basic function - PubMed
As a consequence, differentiated cells develop a stable and unique DNA methylation pattern that regulates tissue-specific gene transcription. In this chapter, we will review the process of DNA methylation and demethylation in the nervous system.
DNA methylation in mammalian development and disease
2024年8月12日 · Here, we summarize the current understanding of the distinct DNA methylation landscapes that emerge over the mammalian lifespan and discuss how they interact with other regulatory layers to ...
Principles of DNA methylation and their implications for …
2018年9月1日 · DNA methylation represents an annotation system for marking the genetic text, thus providing instruction as to how and when to read the information and control transcription.
DNA Methylation: Genomewide Distribution, Regulatory …
DNA methylation is the most important epigenetic modification involved in the regulation of transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin structure. DNA methylation in the genome is often associated ...
DNA Methylation - an overview | ScienceDirect Topics
DNA methylation is a chemical process involving the addition of a methyl group to DNA that changes the DNA’s appearance and structure of DNA, modifying a gene’s interactions with the transcription machinery.
DNA Methylation- Definition, Principle, Significance, Control
2022年1月2日 · DNA methylation is a process by which methyl groups are added to the DNA molecule. It is an epigenetic mechanism that occurs by the addition of a methyl (-CH3) group to DNA, thereby often modifying the function of the genes and affecting gene expression.
DNA Methylation in Solid Tumors: Functions and Methods of …
DNA methylation, i.e., addition of methyl group to 5′-carbon of cytosine residues in CpG dinucleotides, is an important epigenetic modification regulating gene expression, and thus implied in many cellular processes. Deregulation of DNA methylation is strongly associated with onset of various diseases, including cancer.