The Role of Methylation in Gene Expression - Nature
DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression. Aa Aa Aa. There are many ways that gene expression is controlled in eukaryotes, but...
DNA Methylation and Its Basic Function
2012年7月11日 · In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine.
DNA methylation in mammalian development and disease
2024年8月12日 · In mammals, DNA methylation is essential for viability in nearly every fetal and adult cell type and serves as the mechanistic standard for epigenetic transmission over DNA replication 1,2,3,4...
Now and then in eukaryotic DNA methylation
2 天之前 · Since the mid-1970s, increasingly innovative methods to detect DNA methylation provided detailed information about its distribution, functions, and dynamics. As a result, new concepts were formulated and older ones were revised, transforming our understanding of the associated biology and catalyzing unprecedented advances in biomedical research, drug development, anthropology, and evolutionary ...
DNA Methylation As an Epigenetic Mechanism in the …
2020年6月5日 · This review summarizes the data on the molecular mechanisms underlying DNA methylation and the MS risk factors that can affect the DNA methylation profile and, thereby, modulate the expression of the genes involved in the disease’s pathogenesis.
Epigenetic Mechanisms: DNA Methylation and Histone Protein
2022年10月18日 · Methyl-CpG-binding proteins that are able to read and interpret these epigenetic signals provide a connection between DNA methylation and chromatin modification through partnering with chromatin remodeling factors.
Profiling genome-wide DNA methylation - Epigenetics
2016年6月29日 · DNA methylation is tissue-specific, dynamic, sequence-context-dependent and trans-generationally heritable, and these complex patterns of methylation highlight the significance of profiling DNA methylation to answer biological questions.
Genetic impacts on DNA methylation: research findings and future ...
2021年4月30日 · In this review, we summarize recent milestones in characterizing the human genetic basis of DNA methylation variation over the last decade, including heritability findings and genome-wide identification of meQTLs.
DNA methylation and regulation of gene expression: Guardian of …
2021年8月16日 · One of the most critical epigenetic signatures present in the genome of higher eukaryotes is the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA methylation in a locus, it can serve as a repressive or activation mark for gene expression.
Integrated multi-omics reveals contrasting epigenetic patterns in …
2024年10月18日 · DNA methylation, as a conserved and important epigenetic marker, plays a key role in regulating gene expression and modulating numerous biological processes [9]. However, research on DNA methylation and epigenetic studies in wheat, including histone modifications and chromatin accessibility, is considerably less advanced than for other species ...