Herpesvirus DNA polymerase: Structures, functions, and mechanisms
2021年1月1日 · HSV polymerase is the target for the most successful antiherpesvirus drugs such as the nucleoside analogue acyclovir (ACV). As was true for most herpesvirus functions, early studies of herpesvirus DNA polymerases mainly used HSV-infected cells.
Viral DNA polymerase structures reveal mechanisms of antiviral …
Viral family B DNA polymerases are major targets for antivirals, including agents that are active against poxviruses, adenoviruses, and herpesviruses. 1 The herpes simplex virus (HSV) polymerase is the target of the triphosphate (TP) form of the nucleoside analog acyclovir (ACV), the leading antiviral drug for treating HSV infection, and of ...
Herpes Simplex Viruses: Mechanisms of DNA Replication
Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis—UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (polymerase), and UL5/UL8/UL52 (helicase/primase).
The structure and function of the HSV DNA replication proteins
The only currently licensed anti-herpes simplex drug, acyclovir, is an inhibitor of HSV DNA polymerase and is widely held to block viral replication primarily by specifically inhibiting viral DNA replication.
Mechanism of action and selectivity of acyclovir - PubMed
1982年7月20日 · Acyclovir, an acrylic purine nucleoside analog, is a highly potent inhibitor of herpes simplex virus (HSV), types 1 and 2, and varicella zoster virus, and has extremely low toxicity for the normal host cells. This selectivity is due to the ability of these viruses to code for a viral thymidine kinas …
Effects of Acyclovir, Foscarnet and Ribonucleotides on Herpes …
2016年2月2日 · We examined the impact of two clinically approved anti-herpes drugs, acyclovir and Forscarnet (phosphonoformate) on the exonuclease activity of the herpes simplex virus-1 DNA polymerase, UL30. Acyclovir triphosphate and Foscarnet, along with the closely related phosphonoacetic acid, did not affect exonuclease activity on single-stranded DNA.
Acyclovir - StatPearls - NCBI Bookshelf - National Center for ...
2023年5月7日 · Acyclovir is an agent used to treat infections caused by the herpes simplex virus (HSV). It is FDA-approved to treat genital herpes and HSV encephalitis. Non-FDA-approved indications are mucocutaneous HSV, herpes zoster (shingles), and varicella zoster (chickenpox). Acyclovir is the first-line treatment for HSV encephalitis. Currently, no other ...
Acyclovir in the Treatment of Herpes Viruses - A Review
The neurotropic and neuro-invasive properties of HSV are responsible for neurodegenerative illnesses, such as Alzheimer's disease. Acyclovir and its analogues, being the inhibitors of the viral DNA replication, are the only approved medicines for HSV infection therapies.
Resistance of Herpes Simplex Viruses to Nucleoside Analogues ...
Genotypic characterization of drug-resistant isolates can reveal mutations located in the viral TK and/or in the DNA pol genes. Recombinant HSV mutants can be generated to analyze the contribution of each specific mutation with regard to the drug resistance phenotype.
The enzymological basis for resistance of herpesvirus DNA ... - PNAS
1999年1月19日 · Acyclovir (ACV), like many antiviral drugs, is a nucleoside analog. In vitro, ACV triphosphate inhibits herpesvirus DNA polymerase by means of binding, incorporation into primer/template, and dead-...
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