Multifunctional histone variants in genome function
2024年8月13日 · In this Review, the authors provide an overview of the roles of individual histone variants in multiple processes, including gene regulation, DNA replication and DNA repair, and the cellular ...
Histones and histone variant families in prokaryotes
2024年9月11日 · Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different DNA binding properties, in addition to highly divergent sequences.
The roles of histone variants in fine-tuning chromatin …
2021年7月21日 · Histones serve to both package and organize DNA within the nucleus. In addition to histone post-translational modification and chromatin remodelling complexes, histone variants contribute to the complexity of epigenetic regulation of the genome.
H1.0 Linker Histone as an Epigenetic Regulator of Cell Proliferation ...
H1 linker histones are a class of DNA-binding proteins involved in the formation of supra-nucleosomal chromatin higher order structures. Eleven non-allelic subtypes of H1 are known in mammals, seven of which are expressed in somatic cells, while four are germ cell-specific. Besides having a general structural role, H1 histones also have ...
Regulation of chromatin by histone modifications | Cell Research
2011年2月15日 · Histone post-translational modifications. Abstract. Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to external cues to regulate the many uses...
Histone variants at a glance - PubMed
2021年3月26日 · Histone variants confer different structural properties on nucleosomes by wrapping more or less DNA or by altering nucleosome stability. They carry out specialized functions in DNA repair, chromosome segregation and regulation of transcription initiation, or perform tissue-specific roles.
Histone acylations and chromatin dynamics: concepts, …
2021年6月23日 · During native chemical ligation (bottom panel), the thioester of an acylated peptide (e.g., histone N‐terminus) is linked to the cysteine of the truncated histone core. Acylated histones and remaining core histones can be used to refold octamers and assemble “designer” chromatin on DNA templates.
Contributions of Histone Variants in Nucleosome Structure and …
2021年3月19日 · Analyses of NCP structures with canonical histones from various species have revealed the high conservation of the overall structure among yeasts, flies, amphibians, birds, and mammals. In the NCP, 145 to 147 base pairs of DNA continuously contact the histone octamer at 10 base pair intervals.
H1 histones: current perspectives and challenges | Nucleic Acids ...
2013年8月14日 · Histones are evolutionarily conserved proteins responsible for condensation, organization and regulation of the DNA within the nucleus of all eukaryotes. The basic structural element of DNA compaction, the nucleosome core particle, is made up of superhelical DNA wrapped about a protein octamer composed of two copies of each core histone H2A ...
Histone dynamics during DNA replication stress - PMC
2021年6月19日 · Histone dynamics during replication stress. Selected functions of histone modifications and variants in resolving replication stress are shown. Histone marks and the corresponding catalytic protein (s) are listed along with their main function in resolving certain types of replication stress.