Structures of the nine stereoisomers of inositol. Inositol exists …
Inositol exists under 9 stereoisomeric forms through epimerization of its hydroxyl groups. myo-Inositol (framed) is the most common isomer of inositol in foodstuffs and animal tissues.
Inositol - Wikipedia
In biochemistry, medicine, and related sciences, inositol generally refers to myo-inositol (formerly meso-inositol), the most important stereoisomer of the chemical compound cyclohexane-1,2,3,4,5,6-hexol. Its formula is C 6 H 12 O 6; the molecule has a ring of six carbon atoms, each with an hydrogen atom and a hydroxyl group (–OH).
The Biomedical Uses of Inositols: A Nutraceutical Approach to …
Given their structure, there are at least eight isomers of inositols that occur in nature (myo-, muco-, neo-, scyllo-, l-chiro-, d-chiro-, epi-, and allo-inositol) and one non-occurring in nature (cis-inositol) (Figure 1A) . Inositols act as second messengers of the insulin-signaling pathway and their administration exerts insulin-sensitizing ...
Inositols - Yale University
There are nine possible stereoisomers, the first seven of which, as listed above, are optically inactive. Assigning CIP-R/S-r/s configurations to carbon atoms in the inositols is not trivial. Any carbon lying in a plane of symmetry is stereogenic and achirotopic and it is designated as r/s.
Inositols: From Established Knowledge to Novel Approaches
Myo-inositol and D-chiro-inositol are the most common isomers of inositol. Myo-Ins is an organic osmolyte that regulates cellular responses to hypertonic environments. Although myo-Ins absorption can occur by a diffusion process when it is highly concentrated, inositols uptake by cells is primarily carried out by a complex system of ...
Inositol - PubChem
Inositol is a collection of nine different stereoisomers but the name is usually used to describe only the most common type of inositol, myo-inositol. Myo-inositol is the cis-1,2,3,5-trans-4,6-cyclohexanehexol and it is prepared from an aqueous extract of corn kernels by precipitation and hydrolysis of crude phytate.
Inositols and metabolic disorders: From farm to bedside - PMC
Inositols derive from both diet and endogenous production; among causes of inositol deficiency reduced dietary intake, increased catabolism and/or excretion, decreased biosynthesis, inhibition of gut and cellular uptake and altered microbiota could be considered.
The inositol phosphate signalling network in physiology and disease
2024年11月1日 · Of nine possible isomers, the myo-isomer [referred to inositol (Ins) in the main text] constitutes the carbon skeleton of the InsPs present in mammals, yeast, plants, and the vast majority of organisms. The examples shown here provide a guide to understand the structure–nomenclature relationship used to describe all InsPs and inositol ...
Inositol - an overview | ScienceDirect Topics
Inositol is an isomer of glucose and is present in high concentrations in the brain. It is part of intracellular processes mediated by second messenger systems, and may be involved in regulating the activity of monoamines (especially serotonin, with possible action on dopamine and norepinephrine) as well as other neurotransmitters.
Isomer-selective analysis of inositol phosphates with differential ...
2022年1月25日 · Myo-inositol (hereafter I) is the predominant and most intensively studied stereoisomer of inositol, a cyclohexane-1,2,3,4,5,6-hexol (structure shown in Fig. 1) [1]. Arising from phosphorylation at hydroxy groups, myo-inositol phosphates (IPx) are formed.