The Central Role of Glucokinase in Glucose ... - PubMed Central …
It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals. This includes other cells in ...
15.4: Regulation of Glycolysis - Biology LibreTexts
2024年5月22日 · Hexokinase IV or Glucokinase is specifically expressed within the liver and pancreas. HKIV is cytoplasmic and not tethered to the mitochondria. Activity within the pancreas serves as a sensor for the release of insulin, and in the liver for the production of G6P that will fuel glycogen production.
13.1: Glycolysis - Biology LibreTexts
2023年9月27日 · In the second step of glycolysis, the phosphoglucose isomerase (PGI) converts glucose-6-phosphate into one of its isomers, fructose-6-phosphate. Recall that an isomerase is an enzyme that catalyzes the conversion of a molecule into one of its isomers.
GLYCOLYSIS - NYU Langone Health
Glucokinase gene transcription is stimulated by insulin, a hormone secreted by the pancreatic β cells in response to high blood glucose levels. Glucokinase is a better sensor of glucose concentration than is Hexokinase because its sensitivity to glucose extends over a longer range of glucose concentration.
Glucokinase (GCK) in diabetes: from molecular mechanisms to …
2024年9月8日 · Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver.
Molecular Physiology of Mammalian Glucokinase - PMC
Mammalian glucokinase is able to phosphorylate hexoses like mannose or fructose in addition to glucose, a property shared with three other hexokinases present at various levels and in various combinations in human, rat, and mouse tissues [1].
Biochemistry, Glycolysis - StatPearls - NCBI Bookshelf
2023年8月8日 · Glucokinase is a subtype of hexokinase found in humans. Glucokinase has a reduced affinity for glucose and is found only in the pancreas and liver, whereas hexokinase is present in all cells. Glucose 6-phosphate is then converted to fructose-6-phosphate, an isomer, by phosphoglucose isomerase.
Molecular Physiology of Mammalian Glucokinase | Cellular and …
2008年8月26日 · Hormone and nutrient regulation of glucokinase gene expression in islets of Langerhans. Glucose refeeding after a fast is an experimental paradigm often used to study acute hyperinsulinemia in the intact animal.
Carbohydrate Metabolism A: Glycolysis and Gluconeogenesis
2011年1月1日 · There are four hexokinase isozymes: Hexokinase I from brain (HKI), hexokinase II from skeletal muscle (HKII), hexokinase III, and hexokinase IV, also known as glucokinase, which is found primarily in mammalian liver and to some extent in brain and pancreas. In the latter tissue, it acts as a glucose sensor for insulin secretion.
The Central Role of Glucokinase in Glucose Homeostasis: A ... - PubMed
2019年3月6日 · Raising glucose concentration increases intramitochondrial [NADH]/ [NAD +] and thereby the energy state ( [ATP]/ [ADP] [Pi]), decreasing [Mg 2+ ADP] and [AMP]. [Mg 2+ ADP] acts through control of K ATP channel conductance, whereas [AMP] acts through regulation of AMP-dependent protein kinase.