Phosphodiester bond - Wikipedia
In chemistry, a phosphodiester bond occurs when exactly two of the hydroxyl groups (−OH) in phosphoric acid react with hydroxyl groups on other molecules to form two ester bonds. The "bond" involves this linkage C−O−PO− 2O−C. [1] .
Liaison phosphodiester — Wikipédia
La liaison phosphodiester correspond au lien entre le phosphore d'un groupement phosphate avec deux autres molécules via deux liens ester. Elle se produit lorsque exactement deux des groupes hydroxyles (-OH) de l' acide phosphorique réagissent avec les groupes hydroxyles d'autres molécules pour former deux liaisons ester.
13.10: Phosphoester Formation - Chemistry LibreTexts
In DNA and RNA, the phosphodiester bond is the linkage between the 3' carbon atom of one sugar molecule and the 5' carbon atom of another, deoxyribose in DNA and ribose in RNA. Strong covalent bonds form between the phosphate group and two 5-carbon ring carbohydrates (pentoses) over two ester bonds.
Chapter 8: Phosphodiesters and Phosphotriesters - Royal Society …
2020年10月29日 · Phosphodiester linkages, typically generated by action of nucleotidyl transferases, are the backbone of three distinct metabolic scaffolds that function in distinct cellular niches. Both RNA polymerases and DNA polymerases generate internucleotide phosphodiester bonds as the sole covalent links in these informational biopolymers.
Phosphodiester linkage - (Biological Chemistry I) - Fiveable
A phosphodiester linkage is a covalent bond that forms between the phosphate group of one nucleotide and the hydroxyl group on the sugar of another nucleotide, creating a sugar-phosphate backbone in nucleic acids like DNA and RNA.
Bonding through phosphodiester moiety: Its implications in ...
2023年1月1日 · A phosphodiester bond is formed by reacting two hydroxyl groups in phosphoric acid with the hydroxyl group on other molecules to produce an ester link. One way to think about the phosphodiester bond is when phosphate makes two ester bonds simultaneously.
What is a phosphodiester bond? | IDT - Integrated DNA …
2024年2月20日 · In DNA or RNA, phosphodiester bonds are the bonds between the phosphate group and the sugar molecules. DNA contains nitrogenous bases (adenine, guanine, cytosine, thymine, or an uracil if it’s RNA), a sugar molecule (deoxyribose if DNA or ribose if RNA), and a triphosphate group (Figure 1).
Phosphorous chemistry in vivo: what makes the phosphoesters …
2017年5月24日 · For example, phosphorylation of proteins serves as signal for specific metabolic pathways, nucleic acid phosphodiester bonds are targets for enzymatic cleavage or are formed by ligation, and energy stored in phosphoester bonds or, even more importantly, in phosphoric anhydrides, is used for driving chemical reactions.
Phosphodiester Bond - an overview | ScienceDirect Topics
The phosphodiester bond is a covalent linkage between the phosphate of one nucleotide and the hydroxyl (OH) group attached to the 3′ carbon of the deoxyribose sugar in an adjacent nucleotide, forming what is known as the “sugar-phosphate backbone” of DNA.
Dynamics of phosphodiester synthesis by DNA ligase
2008年5月5日 · Ligases are essential actors in DNA replication, recombination, and repair by virtue of their ability to seal breaks in the phosphodiester backbone. Ligation proceeds through a nicked DNA-adenylate intermediate (AppDNA), which must be sealed quickly to avoid creating a potentially toxic lesion.