Bupropion - StatPearls - NCBI Bookshelf - National Center for ...
2024年9月2日 · Bupropion and hydroxybupropion are highly lipid-soluble, and intravenous lipid emulsion therapy can help treat bupropion overdose. Successful use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been documented in patients with severe cardiotoxicity associated with bupropion overdose.
Bupropion: Uses, Interactions, Mechanism of Action - DrugBank …
Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation.
A Review of the Neuropharmacology of Bupropion, a Dual …
Research conducted over the past decade has significantly advanced the understanding of the neuropharmacology of bupropion and has demonstrated a novel mechanism of antidepressant activity. This article discusses the mechanism of action of bupropion and relates the drug's neuropharmacologic effects to its clinical efficacy and tolerability ...
Bupropion | C13H18ClNO | CID 444 - PubChem
Bupropion is an aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring. It has a role as an antidepressant, an environmental contaminant and a xenobiotic. It is a secondary amino compound, a member of monochlorobenzenes and an aromatic ketone.
Bupropion: a review of its mechanism of antidepressant activity
Background: The mechanism of action of the novel antidepressant bupropion remains unclear after many years of study. A review of the relevant biochemical, in vivo brain microdialysis, electrophysiologic, behavioral, and clinical data clarifies what is known about this unique compound and suggests possible modes of action.
Review of the Pharmacology and Clinical Profile of Bupropion, an ...
In clinical trials, bupropion is being tested as a candidate treatment for psychostimulant drug abuse, attention‐deficit hyperactivity disorder (ADHD) and obesity. Bupropion is available in three bioequivalent oral formulations, immediate release (IR), …
Bupropion - an overview | ScienceDirect Topics
Bupropion is an atypical antidepressant that acts as a weak inhibitor of neuronal reuptake of noradrenaline and dopamine. It enhances mesocorticolimbic dopaminergic activity and has nicotine receptor antagonist activity, making it effective for …
Bupropion | Definition, Uses, Mechanism of Action, & Side Effects ...
Bupropion, drug that is used to treat depression, to prevent depression in persons with seasonal affective disorder, or sometimes to aid in smoking cessation. Bupropion typically is taken orally in the form of bupropion hydrochloride. Bupropion was developed in 1966 and patented in 1974 by
Bupropion: pharmacology and therapeutic applications - PubMed
The mechanism of action of bupropion is still uncertain but may be related to inhibition of presynaptic dopamine and norepinephrine reuptake transporters. The activity of vesicular monoamine transporter-2, the transporter pumping dopamine, norepinephrine and serotonin from the cytosol into presynaptic vesicles, is increased by bupropion and may ...
Bupropion: pharmacology and therapeutic applications.
The mechanism of action of bupropion is still uncertain but may be related to inhibition of presynaptic dopamine and norepinephrine reuptake transporters. The activity of vesicular monoamine transporter-2, the transporter pumping dopamine, norepinephrine and serotonin from the cytosol into presynaptic vesicles, is increased by bupropion and may ...