Overview of cerebrospinal fluid cytology - PubMed
Macrophages that contain fragments of erythrocytes or hemoglobin degradation products are referred to as erythro- or siderophages, both of which indicate prior subarachnoid hemorrhage. Likewise, the detection of tumor cells is specific for neoplastic meningitis, although false-negative CSF cytologies are frequent.
Cerebrospinal Fluid (CSF) Analysis and Interpretation in …
The analysis following cytokines plays an important role in the diagnosis of spine pathologies: macrophage derived chemokine (MDC/CCL22), granulocyte macrophage colony-stimulating factor GRO/CXCL10, Interleukins (IL-12p70, IP-10/CXCL10), Platelet …
Macrophage compartmentalization in the brain and ... - Science
2022年3月4日 · Whereas most CNS macrophages are tissue-embedded, the macrophages of the cerebrospinal fluid (CSF) system are bathed in an oscillating liquid. Studies using multiomics technologies have recently uncovered the transcriptomic and proteomic profiles of CSF macrophages, enhancing our understanding of their cellular characteristics in both rodents ...
Hausheer F. Dx & Treatment of malignant pleural effusions. Semin Oncol. 1985;12(1):54-75. Diagnosis? Adenocarcinoma often has large vacuoles with a smooth, well-defined border and a clear interior. Vacuoles may coalesce in adjacent cells.
Parenchymal border macrophages regulate the flow dynamics of …
2022年11月9日 · Given their continuous interaction with the cerebrospinal fluid (CSF) and strategic positioning, we refer to these cells collectively as parenchymal border macrophages (PBMs). Here we...
Macrophage inclusions in cerebrospinal fluid following treatment ...
2024年2月22日 · This report presents a case series of CSF cytology findings in two patients with SMA and ALS revealing comparable unspecified macrophage inclusions following treatment initiation with nusinersen and tofersen. Yet, the presence of these “asophages” in the treatment course of two different ASOs is of unclear significance.
Macrophages in health and disease - Cell Press
2022年11月10日 · Macrophages are critical regulators of immunity and play key roles in a range of biological and pathological processes. This review provides a conceptual framework for improving our understanding of the contributions of macrophages of different origins to physiological and disease states.
Macrophages clear the way for CNS fluid flow
Transcriptome profiling and pathway analysis by Drieu and colleagues identified two different subsets of parenchymal border macrophages—highly phagocytotic LYVE1-positive parenchymal border macrophages (that are enriched around arteries), and immune-regulatory MHC class II-positive parenchymal border macrophages (that are increased around veins).
CAR-T therapy toxicities: the importance of macrophages in their ...
4 天之前 · Important to understand along with T-cell cytotoxicity in CAR-T therapies is the MPS. Monocytes, macrophages, and dendritic cells make up a disbursed system, the MPS, which all derive from a common myeloid origin [].This system permeates all tissues and is integral to antigen presentation, innate immune responses, tissue repair, and many other tissue-specific roles [14,15,16,17].
The Pediatric Infectious Disease Journal - LWW
Macrophages in cerebrospinal fluid are described as indicators of pathology. We present findings from the lumbar puncture of a child without neurologic disease. Cerebrospinal fluid obtained after an initial, traumatic lumbar puncture attempt included a high proportion of macrophages, some containing erythrocyte fragments and hemosiderin.