Maleimide | C4H3NO2 | CID 10935 - PubChem
Maleimide is a cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure. It has a role as an EC 5.99.1.3 [DNA topoisomerase ( ATP -hydrolysing)] inhibitor.
Bioconjugation with Maleimides: A Useful Tool for Chemical …
Jan 2, 2019 · Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic accessibility, excellent reactivity, and practicability. The second-generation of clinically approved antibody-drug conjugates (ADC) and much of the current ADC pipeline in clinical trials contain the maleimide l ….
Chemistry – A European Journal
Aug 10, 2018 · Rational design of novel generations of maleimides and maleimide-type reagents have been reported to address the shortcomings of classical maleimides. This review highlights recent developments in the maleimide chemistry focused on bioconjugation strategies.
Maleimide - an overview | ScienceDirect Topics
Maleimide is a particularly versatile heterocycle and considerable effort has been expended in the last 10 years in attaching the group to polymers. By far the most prolific utilization of maleimide and its derivatives as pendant groups on polymers has been for the development of photosensitive materials.
Maleimide - an overview | ScienceDirect Topics
Maleimide is a compound that is part of a heterobifunctional crosslinker, featuring a maleimide group on one end and an NHS ester on the other end. It is used to link amine-containing molecules to thiol-containing molecules, providing control over the conjugation process in scientific applications.
Bioconjugation of Maleimides - Protocol & Theory - Papyrus Bio …
Oct 4, 2021 · We discuss bioconjugation of maleimides to cysteines, reaction mechanisms, hydrolysis, use of maleimide derivatives, protocols, & applications.
Maleimide–thiol adducts stabilized through stretching - Nature
Feb 4, 2019 · Single-molecule force spectroscopy reveals that maleimide–thiol adducts can be stabilized by stretching through a force-dependent kinetic control mechanism.
Maleimide Chemistry: Enabling the Precision Polymer Synthesis
Jul 5, 2021 · Herein is presented a compilation of the main characteristics of maleimide chemistry in developing the precisely controlled polymers, including the design of sequence-controlled polymers, topological polymers, and polymeric single-chain nanoparticles.
Maleimide - an overview | ScienceDirect Topics
N-Ethyl maleimide (NEM) (NEM) is an alkylating reagent that reacts with sulfhydryls to form stable thioether bonds (Smyth et al., 1960). Maleimide reactions are specific for sulfhydryl groups in the pH range of 6.5 to 7.5 (Smyth et al., 1964; Gorin et al., 1966; Heitz et al., 1968; Partis et al., 1983) (see Chapter 3, Section 2.2).
Maleimide | C4H3NO2 - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for Maleimide, 541-59-3, 208-787-4.
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