Morphogen gradients in Development: from form to function
Morphogens are substances that establish a graded distribution and elicit distinct cellular responses in a dose dependent manner. They function to provide individual cells within a field with positional information, which is interpreted to give rise to spatial patterns.
Morphogen gradients: from generation to interpretation
In its simplest incarnation, a morphogen signal forms a gradient by diffusion from a local source and clearance in surrounding tissues. Responding cells often transduce morphogen levels in a linear fashion, which results in the graded activation of transcriptional effectors.
Morphogen gradient interpretation - Nature
2001年10月25日 · A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location,...
Morphogengineering roots: comparing mechanisms of morphogen gradient …
Here we explore how the details of the mechanism which underlies the generation of a morphogen gradient can influence those properties. We contrast three gradient-generating mechanisms, (i) a source-decay mechanism; and (ii) a unidirectional transport mechanism; and (iii) a so-called reflux-loop mechanism.
Patterning principles of morphogen gradients - PMC - PubMed …
Morphogen gradients can relay their positional information content at a precise location through effector molecules via numerous alternative methods, including persistence, rate of change, gradient slope and spatial fold-change (neighbour comparison) of the signal.
Morphogens, their identification and regulation | Development
2004年2月15日 · Morphogens are signaling molecules that emanate from a restricted region of a tissue and spread away from their source to form a concentration gradient. As the fate of each cell in the field depends on the concentration of the morphogen signal, the gradient prefigures the pattern of development.
Generation of extracellular morphogen gradients: the case for ... - Nature
2021年3月25日 · Cells within developing tissues rely on morphogens to assess positional information. Passive diffusion is the most parsimonious transport model for long-range morphogen gradient formation but...
The interpretation of morphogen gradients | Development | The …
2006年2月1日 · Morphogens act as graded positional cues that control cell fate specification in many developing tissues. This concept, in which a signalling gradient regulates differential gene expression in a concentration-dependent manner, provides a basis for understanding many patterning processes.
Genetics of morphogen gradients | Nature Reviews Genetics
Several models have been proposed for generating a morphogen gradient; diffusion through the extracellular space is important in trafficking of the Wg morphogen, and planar transcytosis...
Morphogen Gradients: From Generation to Interpretation
In its simplest incarnation, a morphogen signal forms a gradient by diffusion from a local source and clearance in surrounding tissues. Responding cells often transduce morphogen levels in a linear fashion, which results in the graded activation of transcriptional effectors.
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