Neurofilament light polypeptide - Wikipedia
Neurofilament light polypeptide, also known as neurofilament light chain, abbreviated to NF-L or Nfl and with the HGNC name NEFL is a member of the intermediate filament protein family. …
Neurofilament Light Chain Fact Sheet - Cleveland Clinic
Neurofilament light (NfL) is the most studied neurofilament in human disease and the most commonly-reported neurofilament in research publications. Since neurofilaments are released …
Neurofilament light chain as a biomarker in neurological disorders
Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to …
Neurofilaments as biomarkers in neurological disorders - Nature
2024年4月12日 · High-sensitivity analytical platforms enable reliable quantification of neurofilament light chain (NfL) levels in blood samples, paving the way for their use in clinical …
Neurofilament-Light, a Promising Biomarker: Analytical, …
Neurofilament-light chain (Nf-L) is a reliable biomarker in the context of neurodegenerative diseases (NDD) and traumatic brain injuries (TBI). This protein is found principally in large …
Neurofilaments as biomarkers in neurological disorders
2018年8月31日 · Here, we review what is known about the structure and function of neurofilaments, discuss analytical aspects and knowledge of age-dependent normal ranges of …
Neurofilament Light Chain - an overview | ScienceDirect Topics
Neurofilament Light Chain (NF-L) is a major neuronal cytoskeletal protein that, when increased in the cerebrospinal fluid (CSF), is associated with neurodegeneration and neuroaxonal damage. …
Age‐ and disease‐specific reference values for neurofilament light ...
Neurofilament light chain (NfL) is a biofluid biomarker of neuroaxonal damage. NfL levels are altered in multiple neurological diseases, with disease‐specific elevations and a strong, …
Neurofilament light chain as a biomarker, and correlation with …
Neurofilament light chain (NfL) is a unique biomarker related to axonal damage and neural cell death, which is elevated in a number of neurological disorders, and can be detected in …
Neurofilament light: a narrative review on biomarker utility
2021年5月7日 · Neurofilament light (NfL) is a scaffolding protein that is located primarily within myelinated axons and that provides increased conduction speed and structural support. In …