1,3,4-Oxadiazole-containing hybrids as potential anticancer …
2021年8月1日 · The oxadiazole-based hybrid drug zibotentan, which is in clinical trial opens up a new path for the development of potent and non-toxic 1,3,4-oxadiazole-heterocycle hybrids as …
Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery - PMC
In 2015, Xu L. et al. discovered novel, 1,2,4-oxadiazole-based derivatives as active Nrf2 activators—potent anti-inflammatory agents, which is a continuation of their previous work in …
Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles …
Among heterocyclic compounds, 1,3,4-oxadiazole has become an important construction motif for the development of new drugs. Compounds containing 1,3,4-oxadiazole cores have a broad …
Groundbreaking Anticancer Activity of Highly Diversified Oxadiazole ...
Structural modifications, that ensure higher cytotoxicity towards malignant cells, represent a solid starting point in the development of novel oxadiazole-based drugs. To increase the specificity …
Oxadiazole derivatives: Histone deacetylase inhibitors in …
2022年8月1日 · Recently, five drugs namely Vorinostat (SAHA), Romidepsin (FK-228), Belinostat (PXD-101), Panobinostat (LBH-589), and Chidamide have been granted by US/Chinese FDA …
An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole …
2023年2月7日 · In the development of novel 1,3,4-oxadiazole-based drugs, structural modifications are important to ensure high cytotoxicity towards malignant cells. These …
Oxadiazole derivatives can be found in marketed drugs such as Raltegravir - an antiretroviral drug against HIV, Ataluren - in treating cystic fibrosis, Tiodazosin, and Nesapidil used as …
Oxadiazole: A highly versatile scaffold in drug discovery
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the problem associated with the confluence of many commercially available drugs with different …
Oxadiazol-based mTOR inhibitors with potent antiproliferative ...
2022年1月5日 · Several scaffolds of oxadiazole-based analogues were reported in the literature as potent mTOR inhibitors with antiproliferative activities. Lim et al. described the synthesis of …
2. Oxadiazole - PubMed Central (PMC)
Wang et al. designed and synthesised a series of novel nitrofuranamide based-1,3,4-oxadiazole hybrids as new anti-tuberculosis drugs. Some of them showed considerable activity against …