The functions and regulation of the PTEN tumour suppressor
2018年6月1日 · In the cytoplasm, scaffolding by PTEN modulates the activity of inositol 1,4,5-trisphosphate receptors (IP3Rs) and, consequently, Ca 2+-mediated apoptosis. Both wild-type PTEN and a...
PTEN Alterations and Their Role in Cancer Management: Are We …
2020年6月28日 · Phosphatase and tensin homolog (PTEN) is a key tumor suppressor that inhibits cell growth and enhances cellular sensitivity to apoptosis [1]. Since its first discovery in 1997, the role of PTEN as a biomarker in cancer has become more and more significant [2, 3].
The functions of tumor suppressor PTEN in innate and adaptive
2017年6月26日 · The tumor suppressor phosphatase and tensin homolog (PTEN) is a lipid and protein phosphatase that is able to antagonize the PI3K/AKT pathway and inhibit tumor growth....
Over expression of PTEN induces apoptosis and prevents cell ...
2020年12月17日 · We showed that PTEN over expression significantly declined the cell proliferation rate during logarithmic growth phase. Furthermore, the PTEN over expression leads to the activation of mitochondrial based intrinsic apoptosis pathways, which is confirmed by the activation and over expression of caspases 9 and caspases 3.
PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent …
2018年2月19日 · In the cytoplasm, PTEN interacts with its cytoplasmic targets to regulate cell proliferation, cell cycle progression, apoptosis, cell adhesion, migration and invasion. In the nucleus, PTEN plays a role in maintaining chromosomal stability and in DNA double strand break repair [ 6 , 22 ], hence maintaining genome integrity.
Suppression of PTEN Expression by NF-κB Prevents Apoptosis
Restoration of PTEN expression inhibited NF-κB transcriptional activity and augmented TNF-induced apoptosis, indicating a negative regulatory loop involving PTEN and NF-κB. PTEN is, thus, a novel target whose suppression is critical for antiapoptosis by NF-κB.
The functions and regulation of the PTEN tumour suppressor
2012年4月4日 · PTEN antagonizes the phosphoinositide 3-kinase (PI3K)–AKT–mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity and governs a plethora of cellular processes...
Tumor suppressor PTEN: modulator of cell signaling, growth, …
2001年7月1日 · PTEN (also known as MMAC-1 or TEP-1) is one of the most frequently mutated tumor suppressors in human cancer. It is also essential for embryonic development. PTEN functions primarily as a lipid phosphatase to regulate crucial signal transduction pathways; a key target is phosphatidylinositol 3,4,5-trisphosphate.
PTEN induces apoptosis and cell cycle arrest through ... - PubMed
2001年2月1日 · The tumour suppressor PTEN inhibits cell growth through multiple mechanisms. We have previously demonstrated that overexpression of PTEN in MCF-7 breast cancer cells causes G(1) arrest followed by cell death, the latter of which is believed to be mediated by the phosphoinositol-3-kinase (PI3K) and A …
PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor
2022年7月28日 · Here, we review the PTEN mutations and protein-phosphatase substrates in tumorigenesis and metastasis. Our purpose is to clarify how PTEN protein phosphatase contributes to its tumor-suppressive functions through PI3K-independent activities.