Pathology Outlines - Autoimmune pancreatitis type 1
2024年4月22日 · Characteristic histologic findings are periductal lymphoplasmacytic infiltrate without granulocytic infiltration, obliterative phlebitis, storiform fibrosis and abundant IgG4 positive plasma cells Terminology
Key histologic features of IgG4-RD in type 1 AIP. a Diffuse...
In 2011, chronic fibroinflammatory processes occurring simultaneously or metachronously in various organs and associated with elevated IgG4 serum levels and/or tissue infiltration with...
Current status of type 1 (IgG4-related) autoimmune pancreatitis
Histologically, LPSP is characterized by lymphoplasmacytic infiltration, storiform fibrosis, and obliterative phlebitis. These features represent the pathological basis of the disease that is referred to as AIP [2]. In 1995, Yoshida et al. proposed the concept of AIP [3].
Autoimmune pancreatitis: a guide for the histopathologist
There are 2 forms of the disease: (1) type 1 AIP characterized by storiform type fibrosis, obliterative phlebitis, and elevated numbers of immunoglobulin G4 (IgG4) positive plasma cells, typically >50 per high-power field, and, (2) type 2 AIP characterized by granulocytic epithelial lesions and only occasional IgG4-bearing plasma cells ...
Branch Duct – IPMN and PanIN, in IgG4‐Autoimmune pancreatitis: …
Immunostaining confirmed the presence of abundant IgG4‐positive cells (>10 cells/HPF) in the pancreatic parenchyma (Figure 3A), with diagnosis of IgG4‐related autoimmune pancreatitis. Moreover, fascin staining revealed an invasive component of the BD‐IPMN, with evident fascin‐positive areas of stromal infiltration (DakoCytomation, clone ...
Diagnosis and management of IgG4-related disease
IgG4-RD is characterised by unique histological features of lymphoplasmacytic infiltration, storiform fibrosis and obliterative phlebitis. In this review we describe the pancreaticobiliary manifestations of IgG4-RD, with particular emphasis on type 1 autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-SC).
Autoimmune pancreatitis: Biopsy interpretation and differential ...
2024年3月1日 · Histologically, pancreatic biopsies show loose fibrosis, stromal edema, an increased number of small ductules, and neutrophilic infiltration (Fig. 5; Table 2). Although neutrophils may be present around ducts or ductules, potentially resembling GEL, the lack of a background lymphoplasmacytic infiltrate excludes the possibility of type 2 AIP.
Autoimmune pancreatitis in the context of IgG4-related disease: …
2014年11月7日 · IgG4-related disease has been recently-recognized as a systemic inflammatory disorder characterized by stereotypic histopathological features of a dense lymphoplasmacytic infiltrate, “storiform” fibrosis, and obliterative phlebitis [ 7, 8 ]. It is a systemic process which may involve one or multiple organs, either synchronously or metachronously.
IgG4-Related Disease Histology - Rare Disease Advisor
There are 5 histopathological patterns in IgG4-related lymphadenopathy: nodal inflammatory pseudotumor-like, multicentric Castleman disease-like, interfollicular expansion, follicular hyperplasia, and progressive transformation of germinal center-like. Nodal inflammatory pseudotumor-like signifies the most specific pattern for IgG4-RD.
The Histopathology of IgG4-Related Disease | SpringerLink
2016年11月16日 · Histology highly suggestive of IgG4-RD requires at least two histopathological features, which include a dense lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. In addition, an increased number of IgG4-positive plasma cells greater than the cutoff point and an elevated IgG4/IgG cell ratio of more than 40 % need to be ...
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