The Role of Methylation in Gene Expression - Nature
For many years, methylation was believed to play a crucial role in repressing gene expression, perhaps by blocking the promoters at which activating transcription factors should bind.
Promoter DNA Hypermethylation and Paradoxical Gene Activation
We present current evidence documenting promoter hypermethylation and high levels of gene expression, offer insights into the possible mechanisms by which this occurs, and discuss the potential implications for both research and clinical applications.
Large-scale manipulation of promoter DNA methylation reveals …
2022年7月26日 · Here, we simultaneously induce methylation at thousands of promoters in human cells using an engineered zinc finger-DNMT3A fusion protein, enabling us to test the effect of forced DNA methylation upon transcription, chromatin accessibility, histone modifications, and DNA methylation persistence after the removal of the fusion protein.
DNA methylation 101: what is important to know about DNA methylation …
DNA methylation occurs in CpG nucleotides that are distributed unevenly across the genome. DNA methylation patterns are cell and tissue specific. Methylation of CpGs in the promoter region is associated with gene repression. Hypomethylation in the promoter region and hypermethylation in the gene body are associated with gene expression.
Asymmetrical Evolution of Promoter Methylation of Mammalian …
2024年12月17日 · Promoter Methylation Levels of Recent Duplicates Correlate with the Degree of Conserved Synteny. We considered whether promoter hypermethylation after gene duplication affected all gene copies equally, or whether certain gene copies were more affected than others. After gene duplication, 1 copy (known as the “parental copy”) may remain in ...
DNA Methylation: Genomewide Distribution, Regulatory …
DNA methylation is the most important epigenetic modification involved in the regulation of transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin structure. DNA methylation in the genome is often associated with transcriptional repression and the formation of closed heterochromatin.
Promoter DNA methylation and transcription factor …
2024年9月18日 · Transcriptional memory is challenging to decode with traditional methods. Using synthetic biology approaches, we show that memory is linked to promoter CpG methylation and the TF’s propensity for biomolecular condensation.
Promoter DNA Hypermethylation and Paradoxical Gene …
2020年3月4日 · We present current evidence documenting promoter hypermethylation and high levels of gene expression, offer insights into the possible mechanisms by which this occurs, and discuss the potential implications for both research and clinical applications.
Gene promoter methylation and cancer: An umbrella review
2019年8月20日 · Gene promoter methylation is a common epigenetic event, taking place in the early phase of tumorigenesis, which has a great potential as a diagnostic and prognostic cancer biomarker. In this umbrella review, we provide an overview on the association between gene-promoter methylation of protein-codin …
Changes in correlation between promoter methylation and gene …
2015年10月28日 · Aberrant promoter methylation is considered a hallmark of cancer involved in silencing of tumor suppressor genes and activation of oncogenes. However, recent studies have also challenged the simple model of gene expression control by promoter methylation in cancer, and the precise mechanism of and role played by changes in DNA methylation in ...