SR protein - Wikipedia
SR proteins are important in constitutive and alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA by preferentially selecting different splice sites on the pre-mRNA strands to create multiple mRNA transcripts from one pre-mRNA transcript.
SR Proteins: Binders, Regulators, and Connectors of RNA
Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm.
Regulatory Network of Serine/Arginine-Rich (SR) Proteins: The
2022年9月5日 · Serine/arginine-rich (SR) proteins are a type of splicing factor. They play significant roles in constitutive and alternative pre-mRNA splicing, and are involved in post-splicing activities, such as mRNA nuclear export, nonsense-mediated mRNA decay, mRNA translation, and miRNA biogenesis.
The SR protein family of splicing factors: master regulators of …
2009年1月1日 · The SR protein family comprises a number of phylogenetically conserved and structurally related proteins with a characteristic domain rich in arginine and serine residues, known as the RS domain. They play significant roles in constitutive pre-mRNA splicing and are also important regulators of alter …
Serine/Arginine-rich protein family of splicing regulators: New ...
2019年6月1日 · Serine/arginine-rich (SR) proteins bind RNA and function in stress responses. Conserved SR proteins modulate alternative splicing and other aspects of RNA metabolism. New technologies (CRISPR/Cas, TRIBE) enable functional analysis of …
SR Proteins: Binders, Regulators, and Connectors of RNA
2017年1月1日 · Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program.
Regulation of splicing by SR proteins and SR protein ... - Springer
2013年3月24日 · Here, we summarize the rules for SR proteins to function as splicing regulators, which depend on where they bind in exons versus intronic regions, on alternative exons versus flanking competing exons, and on cooperative as well as competitive binding between different SR protein family members on many of those locations.
EVOLUTION OF SR PROTEIN AND HnRNP SPLICING REGULATORY FACTORS
These results demonstrated that canonical SR proteins can promote pre-mRNA splicing activity even in an SR-free organism and suggest that SR proteins did exist before alternative splicing was prevalent.
SR Proteins and Related Factors in Alternative Splicing
SR proteins and SR-related proteins are generally believed to modulate splice site selection via RNA recognition motif-mediated binding to exonic splicing enhancers and RS domain-mediated protein-protein and protein-RNA interactions during spliceosome assembly.
The SR protein family: pleiotropic functions in pre-mRNA splicing
1996年8月1日 · The modu- lar organization of SR proteins suggests a basic mechanism for their function: their RNA-binding domain could recog- nize specific splicing signals and recruit (through interactions mediated by the RS domain) other splicing factors by protein-protein or RNA-protein inter- actions or by promoting RNA-RNA base pairing.