Recombinant Human Glucokinase/GCK Protein, CF - R&D …
Human Glucokinase / GCK protein (7840-GK) is manufactured by R&D Systems. Reproducible results in enzyme activity assays. Learn More...
GCK Enzyme Human Recombinant | Glucokinase Protein | ProSpec
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of Glucokinase results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria.
Recombinant Human Glucokinase protein (ab82190) - Abcam
Recombinant Human Glucokinase protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Recombinant Human Glucokinase/GCK Protein, CF - Bio-Techne
Mutations in GCK have been associated with non‑insulin‑dependent diabetes mellitus (6, 7), maturity‑onset diabetes of the young type 2 (8), and hyperinsulinemia of infancy (9). The enzyme activity was measured using a phosphatase coupled kinase assay (4).
Human Recombinant Glucokinase (from E. coli ) | VWR
Choose specific enzymes for cleaving bonds, removing genomic DNA from RNA preparations, for producing fragments of proteins, or for use in ion exchange chromatography. Enzymes are used in the chemical industry and other industrial applications …
Recombinant Human Glucokinase protein (ab85977) - Abcam
Recombinant Human Glucokinase protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE. Alternative names Hexokinase-4, HK4, Glucokinase, Hexokinase type IV, Hexokinase-D, HK IV, GCK
Glucokinase from Human, recombinant Cat. No. NATE-1696 Lot. No. (See product label) Introduction Description Glucokinase (GK; EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver, pancreas, gut, and brain of humans and most other vertebrates.
SUMOylation of Pancreatic Glucokinase Regulates Its Cellular …
Here, we show that the pancreatic isoform of human glucokinase is SUMOylated in vitro, using recombinant enzymes, and in insulin-secreting model cells. Three N-terminal lysines unique for the pancreatic isoform (Lys-12/Lys-13 and/or Lys-15) may represent one SUMOylation site, with an additional site (Lys-346) common for the pancreatic and the ...
Glucokinase: from allosteric glucose sensing to disease variants
4 天之前 · Human glucokinase (GCK) functions as a glucose sensor in the pancreas and liver, where GCK activity regulates insulin secretion and glycogen synthesis, respectively. GCK’s low affinity for glucose and the sigmoidal substrate dependency of enzymatic turnover enables it to act as a sensor that makes cells responsive to changes in circulating glucose levels. Its unusual kinetic properties are ...
Glucokinase Protein Overview - Sino Biological
Glucokinase (GCK; EC 2.7.1.1) is a structurally and functionally unique member of this family. Glucokinase is expressed only in mammalian liver and pancreatic islet beta cells. Because of its unique functional characteristics, the enzyme plays an …