Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles …
Polshettiwar and Varma reported a novel one-pot solvent-free synthesis of 1,3,4-oxadiazoles 82 by condensation of benzohydrazide 80 and triethylorthoalkanates 81 under microwave irradiation, and efficiently catalyzed by Nafion ® NR50 (solid supported), and phosphorus pentasulfide in alumina (P 4 S 10 /Al 2 O 3) with excellent yields .
Electrosynthesis of oxadiazoles from benzoylhydrazines
2013年9月1日 · A highly efficient electrochemical synthesis of oxadiazoles from facile benzoylhydrazines was developed. A variety of oxadiazoles were obtained with good yields by virtue of this new method.
Benzohydrazide as a good precursor for the synthesis of novel …
2024年6月1日 · The synthesis and biological assessment of 2,5-disubstituted-1,3,4-oxadiazole derivatives from benzo hydrazide and amino acids as novel potential antioxidant and antibacterial agents have been reported. The structures of the new compounds were characterized by physicochemical properties and spectral methods.
Synthesis and Pharmacological Activities of Pyrazole and Oxadiazole …
Kangani, C.O. et al. reported a single pot synthesis of 2,5-disubstituted 1,3,4-oxadiazole 159 by reacting benzohydrazide 158 with carboxylic acid 157 in presence of Deoxo-Fluor as a cyclizing reagent to give 96–98% yield (Scheme 33).
Synthesis, characterisation and evaluation of oxadiazole as …
2020年4月11日 · A unique series oxadiazoles were synthesized by cyclization of benzophenone hydrazide, followed by the nucleophillic alkylation of heterocyclic scaffold. Synthesized title compounds were characterized by the FT-IR, LCMS and NMR spectral techniques. The newly synthesized compounds were screened for the anticancer activity.
Synthesis and evaluation of substituted diphenyl-1,3,4-oxadiazole …
2012年3月1日 · The synthesis was based on ester substitution of substituted benzohydrazide in presence of hydrazine hydrate followed by cyclization in presence of phosphorus oxychloride. All the synthesized compounds were evaluated for their potential CNS depressant activities.
(PDF) Recent advances on oxadiazole motifs: Synthesis
2020年5月12日 · Yu and colleagues synthesized various 1,3,4-oxadiazole derivatives showing fungicidal activity against rice sheath blight (RSB) and sorghum anthracnose (SA), with compounds (58a, EC50: 0.85 mg/L)...
Synthesis of novel benzohydrazone–oxadiazole hybrids as β …
2015年12月1日 · Present work belongs to a simple and reliable synthetic protocol that has been developed for the synthesis of a series of benzohydrazone–oxadiazole hybrid pharmacophores in an effort towards developing more effective agents against β-glucuronidase enzyme.
4-[5-(2-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzohydrazide
2014年5月30日 · 4-(5-(2-Methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzohydrazide (5) was synthesized by three steps. The synthesis started with 2-methoxybenzohydrazide to form hydrazone (3) which was then cyclized to oxadiazole (4) and finally, treatment of oxadiazole (4) with hydrazine hydrate afforded the final product (5).
Synthesis of 1,3,4-oxadiazoles - Organic Chemistry Portal
A mechanochemical synthesis of 2,5-disubstituted 1,3,4-oxadiazoles is an environmentally benign alternative to conventional solvent-based methods. In the presence of triphenylphosphine and trichloroisocyanuric acid, N-acylbenzotriazoles condense with acylhydrazides to provide oxadiazoles derivatives in very good yields within minutes. A range ...