Tetrahydrofuran - Wikipedia
Tetrahydrofuran (THF) is a cyclic ether and a solvent for polyvinyl chloride and other polymers. It is produced by dehydrating 1,4-butanediol or hydrogenating furan or allyl alcohol.
Hydroboration-Oxidation of Alkenes - Chemistry LibreTexts
Learn how to use hydroboration-oxidation to produce alcohols from alkenes in an anti-Markovnikov manner. See the mechanism, examples, problems and references for this reaction.
Hydroboration Oxidation of Alkenes - Chemistry Steps
THF (tetrahydrofuran) is the solvent that is used to stabilize the BH 3 which otherwise tends to form a dimer, B 2 H 6 – a flammable, toxic, and explosive gas: It is a few-steps transformation that starts from the addition of borane (BH 3) to the alkene. This is called hydroboration and it is an electrophilic addition to the alkene.
Tetrahydrofuran - an overview | ScienceDirect Topics
Tetrahydrofuran (THF) is commonly used as solvent, reaction medium, and starting material for various syntheses in the chemical industry, for example, for preparing adhesives, special paints, coatings, fibers, in the extraction of specific active substances, for recrystallization of certain compounds or as starting material for various ...
Hydroboration Oxidation of Alkenes – Master Organic Chemistry
2013年3月28日 · Hydroboration-oxidation is an addition reaction that results in the formation of alcohols. A classic reagent for hydroboration is borane (BH 3) and related reagents (e.g. BH 3 •THF) which can perform hydroborations on up to three molar equivalents of alkene. Substituted organoboranes such as disiamyl borane and 9-BBN have a single B-H bond ...
Hydroboration–oxidation reaction - Wikipedia
Hydroboration–oxidation is an anti-Markovnikov reaction, with the hydroxyl group attaching to the less-substituted carbon. The reaction thus provides a more stereospecific and complementary regiochemical alternative to other hydration reactions such as acid-catalyzed addition and the oxymercuration–reduction process.
Hydroboration of Alkenes – Master Organic Chemistry
This article provides information about the hydroboration reaction using BH3 and its variants. It highlights that hydroboration follows an anti-Markovnikov addition pattern, and the stereochemistry is always syn. The mechanism of the reaction is …
Turning solvents into something - Nature Reviews Chemistry
2022年7月22日 · Tetrahydrofuran (THF) is most commonly known as a solvent in synthetic chemistry because of its high stability, low cost and ideal polarity for the dissolution of a wide range...
11.10: Hydroboration–Oxidation - Chemistry LibreTexts
Learn how to use disiamylborane, a bulky hydroboration reagent, to convert terminal alkynes to aldehydes or methyl ketones. See the mechanism, examples and stereospecificity of this reaction.
Direct C–H metallation of tetrahydrofuran and application in flow
2022年6月30日 · It is well known that the reaction of THF with strong bases causes the decomposition of THF. On reaction with strong bases, α-anionic THF is generated, which undergoes spontaneous...