Regulatory T cell - Wikipedia
The regulatory T cells (Tregs / ˈ t iː r ɛ ɡ / or T reg cells), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease.
How regulatory T cells work | Nature Reviews Immunology
Regulatory T (T Reg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial...
The regulation and differentiation of regulatory T cells and their ...
2024年2月19日 · The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central role in regulating immune responses provided a deeper understanding of self-tolerance.
Regulatory T cells: Purpose, Function & Development - Cleveland Clinic
2022年7月13日 · Regulatory T cells, also called Tregs, are white blood cells that regulate your immune system response. Tregs control how your immune system reacts to unwelcome substances from outside and inside your body.
Principles of regulatory T cell function: Immunity - Cell Press
2023年2月14日 · Treg cells are an immunosuppressive lymphocyte subset essential for preventing autoimmunity. Dikiy and Rudensky review the mechanisms by which Treg cells prevent autoimmunity, mitigate inflammation, and support tissue function.
Regulatory T Cells: Regulation of Identity and Function
2021年10月5日 · The immune system maintains a pool of Regulatory T cells (Tregs), a discrete population of CD4+ lymphocytes that regulates both innate and adaptive immune responses towards self-antigens, virulent agents, cancer, commensal …
Systems immunology of regulatory T cells: can one circuit explain …
2023年9月8日 · Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular circuits involving Tregs and other cell types across space and time.
Regulatory T Cells: Mechanisms of Differentiation and Function
Regulatory T (Treg) cell–mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and …
The discovery of regulatory T cells - Nature
2022年12月6日 · The cells — which became known as ‘regulatory T cells’ — prevented the immune system from over-reacting to tissues of the body. For decades, some researchers had doubted whether these cells...
Human Regulatory T Cells: Understanding the Role of Tregs in …
2023年1月12日 · Regulatory T cells (Tregs) play an important role in maintaining immune tolerance and homeostasis by modulating how the immune system is activated. Several studies have documented the critical role of Tregs in suppressing the functions of effector T cells and antigen-presenting cells.