Tyrosinase - Wikipedia
Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. It is found inside melanosomes which are synthesized in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene. [6]
酪氨酸酶 - 维基百科，自由的百科全书
酪氨酸酶. 酪氨酸酶 （英語： Tyrosinase）是一种 氧化酶，且是调控 黑色素 生成的 限速 酶。. 这种酶参与黑色素合成的两个反应：第一步将单酚羟基化为二酚，第二步将邻二酚氧化为邻二醌。. 邻二醌再经过几步反应后就变为黑色素 [1]。. 酪氨酸酶是一种含 銅 的 ...
酪氨酸酶 - 百度百科
酪氨酸酶又称 多酚氧化酶，是一种约75ku含铜的 氧化还原酶，广泛存在于动植物、微生物及人体中，是黑色素合成的限速酶，直接影响黑色素的合成。酪氨酸酶由多个亚基组成，每个亚基含有2个金属铜离子，而2个铜离子分别与3个组氨酸残基的亚氨基共价结合 ...
Tyrosinase - an overview | ScienceDirect Topics
Tyrosinase, a copper-containing glycoprotein, is the rate-limiting enzyme critical for melanin biosynthesis in specialized organelles termed melanosomes that are produced only by melanocytic cells. Inhibitors of tyrosinase activity have long been sought as therapeutic means to treat cutaneous hyperpigmentary disorders.
Structure and Function of Human Tyrosinase and Tyrosinase-Related ...
2018年1月2日 · In this review, we summarize recent advances on the structure and function of TYR and TYRPs by virtue of the crystal structure of human TYRP1, which is the first available structure of a mammalian melanogenic enzyme.
酪氨酸酶抑制剂综述 - 知乎 - 知乎专栏
2022年10月9日 · 酪氨酸酶（Tyrosinase）是一种广泛分布于不同生物体中的含有多个铜离子的生物酶，在黑色素的生成和酶促褐变过程中发挥着重要作用。. 因此，其抑制剂可以作为美白剂在化妆品和医药行业中具有广泛应用，也可以作为抗褐变化合物应用在食品和农产品中 ...
Tyrosinase enzyme and its inhibitors: An update of the literature
2024年1月1日 · Tyrosinase (EC 1.14.18.1, TYR), also known as polyphenol oxidase, is a copper-containing oxidation enzyme, broadly distributed in plants, animals, and microorganisms [1]. This enzyme plays an essential role in the production of melanin, by being involved in two different reactions of melanin synthesis: monophenolase and diphenolase activities.
Structure–function correlations in tyrosinases - PMC
The Overall Structure of Tyrosinases. The overall structure of tyrosinase can be divided into three domains: the central domain, the N-terminal domain, and the C-terminal domain. 9 The central domain, which is composed of six conserved histidine residues, contains the CuA and CuB oxidizing ions. Although, it is the most conserved domain among tyrosinases, CO and Hc (), the CuB site exhibits ...
Tyrosinase: A Central Regulatory Protein for Cutaneous Pigmentation ...
2012年12月1日 · Tyrosinase is the central and rate-limiting enzyme in melanin biosynthesis. Therefore, elucidation of the molecules and pathways that regulate tyrosinase levels and activity could identify target areas for the development of compounds to decrease excessive pigmentation on one hand or induce pigmentation on the other.
Tyrosinase: Overview - SpringerLink
2017年4月27日 · Tyrosinase (EC 1.14.18.1) is an 80 kD melanosomal membrane-bound glycoenzyme comprising 529 amino acids. It is the principal enzyme involved in the biosynthesis of melanin pigments. Tyrosinase, encoded by the gene TYR (11q14-21, MIM 606933), is expressed in epidermal, follicular, and ocular melanocytes (Hearing 2011).