Vancomycin: Parenteral dosing, monitoring, and adverse ... - UpToDate
Penetration of vancomycin varies by site and concomitant disease state. For example, limited cerebrospinal fluid penetration may be enhanced by the presence of inflamed meninges. Penetration of vancomycin into soft tissue may be impaired in patients with diabetes [12].
Extremely high levels of vancomycin can cause severe renal toxicity
We present a case of vancomycin-induced nephrotoxicity resulting in both acute interstitial nephritis and tubular cells damage confirmed by renal biopsy. Peak and trough levels of 77.11 and 63.60 μg/mL, respectively, were obtained at the first plasma determination.
Vancomycin - StatPearls - NCBI Bookshelf - National Center for ...
2024年10月29日 · Ototoxicity is a rare complication of vancomycin monotherapy and is common in patients receiving excessive vancomycin doses, concurrent ototoxic medications (eg, aminoglycosides, loop diuretics, antineoplastic agents), and …
Review of vancomycin-induced renal toxicity: an update - PMC
Although most vancomycin-induced AKI cases are mild and therefore reversible, their occurrence may be associated with greater incidence of end-stage kidney disease and higher mortality rate. The strategy for its prevention includes adequate renal perfusion and therapeutic drug monitoring in high-risk individuals.
What Is Vancomycin Toxicity? - iCliniq
2023年8月4日 · Vancomycin toxicity refers to the harmful effects that can occur when the antibiotic Vancomycin is misused or at high doses. Vancomycin is generally safe when used properly, but as with any other medication, there is a possibility of experiencing side effects.
The Whole Price of Vancomycin: Toxicities, Troughs, and Time
Nephrotoxicity, which is usually reversible, is the most serious common adverse effect of vancomycin. Vancomycin-associated nephrotoxicity prolongs hospital stays, imposes a need for additional antibiotics and, in rare circumstances, dialysis treatment, and …
Vancomycin dosing, monitoring and toxicity: Critical review of …
Gram-positive pathogens are very common in hospitalized patients with septic shock, so vancomycin has been the antimicrobial of choice for more than 60 years. However, discussions about its dosage, administration and monitoring are extremely important, considering the risk of nephrotoxicity and the emergence of resistant S. aureus.
Vancomycin-induced nephrotoxicity: mechanism, incidence, risk factors ...
2012年3月13日 · In this review, we have collected available evidence on the nephrotoxicity of vancomycin, particularly in terms of its mechanism, incidence, predisposing factors and special target populations. The data were collected by searching Scopus, PubMed, Medline, and Cochrane database systematic reviews.
Vancomycin-induced nephrotoxicity: mechanism, incidence, risk …
In this review, we have collected available evidence on the nephrotoxicity of vancomycin, particularly in terms of its mechanism, incidence, predisposing factors and special target populations. Method: The data were collected by searching Scopus, PubMed, Medline, and Cochrane database systematic reviews.
Vancomycin nephrotoxicity: A comprehensive clinico-pathological …
2024年3月7日 · One of the more frequent side effects of vancomycin is nephrotoxicity (VNT), which is reported in up to 25% of patients and manifests clinically as acute kidney injury (AKI) developing de novo or from a background of chronic kidney injury (CKI) [2].