Chemosensitivity - an overview | ScienceDirect Topics
CO 2 /H + chemosensitivity refers to the effects of acid or CO 2 on respiratory drive and output. For decades it was widely believed that CO 2 and acid chemosensitivity occurred entirely at the central chemoreceptors, which is still a commonly encountered view.
An overview of chemosensitivity testing - PubMed
This overview chapter presents the importance of chemosensitivity testing for screening new therapeutic agents, identifying patterns of chemosensitivity for different types of tumors, establishing patterns of cross-resistance and sensitivity in treatment naive and relapsing tumors; identifying genom …
Chemosensitivity - an overview | ScienceDirect Topics
Chemosensitivity or chemodetection refers to the response of a described unit, say a particular type of neuron, to changes in CO2/pH. From: Seldin and Giebisch's The Kidney (Fourth Edition), 2008
Chemosensitivity - an overview | ScienceDirect Topics
Chemosensitivity A measure of the efficiency of a drug treatment based upon the number of cells alive after a given treatment. A marker that differentiates between patients who will and will not respond to a particular therapy.
mTOR inhibition attenuates chemosensitivity through the …
2022年11月17日 · Here we report a reversible chemoresistance phenotype regulated by the mTOR pathway. Through a genome-wide CRISPR knockout library screen in pancreatic cancer cells treated with chemotherapeutic...
肿瘤药敏测试原理 - CancerCare.hk
它可以检测在血液中的循环流动肿瘤细胞（Circulating Tumour Cells）和循环游离 DNA （Circulating Free DNA），或帮助识别和诊断某些类别的癌症，同时也可以用于监测癌症的变化。 透过肿瘤药敏测试，可以检测在血液循环中已存在的肿瘤细胞，并测量其在血液中的浓度。 这些细胞是从原始肿瘤中分离出来，并进入血液、淋巴系统或身体的其他部分。 简单来说，循环流动肿瘤细胞就像癌症扩散的种子，能通过血液到达身体各处。 由于这些细胞可能会导致癌症复发， …
The molecular mechanisms of chemoresistance in cancers
Chemoresistance causes disease relapse and metastasis, challenges the improvement of clinical outcome for the cancer patients, and remains the main obstacle to cancer therapy. Therefore, it is very important to understand its molecular mechanisms, and find out novel therapeutic approaches for cancer therapy.
Targeting TRAF6/IRF3 axis to inhibit NF-κB-p65 nuclear ... - Nature
2024年12月20日 · Chen, S., Zhang, D., Du, Y. et al. Targeting TRAF6/IRF3 axis to inhibit NF-κB-p65 nuclear translocation enhances the chemosensitivity of 5-FU and reverses the proliferation of gastric cancer.
Evaluation of chemosensitivity prediction using quantitative dose ...
2013年1月22日 · We evaluated a total of 43 advanced primary and relapsed gastric cancers for chemosensitivity based on drug dose response curves to improve the objectivity and quality of quantitative measurements. The dose response curves were …
Chemosensitivity: Volume I: In Vitro Assays | SpringerLink
Chemosensitivity, Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and non-adherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays.