Coenzyme A - Wikipedia
Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester) as a substrate.
辅酶A - 百度百科
辅酶A（coenzyme A），是一种辅酶，值得注意的是其在合成和氧化脂肪酸的角色，和在三羧酸循环中氧化丙酮酸。 所有基因组测序日期编码的酶，即利用辅酶A作为底物，并在4%左右的细胞酶中使用（或硫酯，例如乙酰-CoA）作为基材。
辅酶A - 维基百科，自由的百科全书
辅酶A （英語： coenzyme A，簡稱 CoA 、 CoASH 或 HSCoA）是一種 輔酶，值得注意的是其在合成和氧化 脂肪酸 的角色，和在 三羧酸循環 中氧化 丙酮酸。 利用輔酶A作為 底物，並在4％左右的細胞酶中（或 硫酯，例如 乙酰-CoA）作為基材。 在人類中，輔酶A生物合成需要 半胱氨酸 、 泛酸 和 三磷酸腺苷 （ATP）。 主要參與脂肪酸以及丙酮酸的代謝。 辅酶A是泛酸在生物体内主要活性形式，由3',5'-ADP以磷酸酐键连接4-磷酸泛酰-β-巯基乙胺形成。 辅酶A所含活泼巯基可 …
Coenzyme A - an overview | ScienceDirect Topics
Coenzyme A is an ubiquitous cofactor involved in cellular oxidative pathways including fatty acid β-oxidation, carbohydrate and amino acid oxidations, and Krebs cycle; and in lipid synthesis, protein modifications and membrane trafficking [78,79].
Coenzyme a Biochemistry: From Neurodevelopment to …
2021年8月2日 · Coenzyme A (CoA) is an essential cofactor in all living organisms. It is involved in a large number of biochemical processes functioning either as an activator of molecules with carbonyl groups or as a carrier of acyl moieties.
2016年8月24日 · The central role of coenzyme A (CoA) (see Supple mentary information S1 (figure)) in energy and fatty acid metabolism has been firmly established since its discovery more than 70 years ago as the...
Coenzyme A biosynthesis: mechanisms of regulation, function
2024年6月13日 · The pivotal metabolic cofactor coenzyme A (CoA) functions at the nexus of catabolism, anabolism and metabolic signalling. As a specialized low-molecular-weight thiol, it serves as the...
Probing coenzyme A homeostasis with semisynthetic biosensors
2022年10月31日 · Coenzyme A (CoA) is one of the central cofactors of metabolism, yet a method for measuring its concentration in living cells is missing. Here we introduce the first biosensor for measuring CoA...
Coenzyme A biosynthesis: mechanisms of regulation, function
The tricarboxylic acid cycle, nutrient oxidation, histone acetylation and synthesis of lipids, glycans and haem all require the cofactor coenzyme A (CoA). Although the sources and regulation of the acyl groups carried by CoA for these processes are …
Coenzyme A: Back in action - ScienceDirect
2005年3月1日 · Coenzyme A (CoA) is a ubiquitous essential cofactor that plays a central role in the metabolism of carboxylic acids, including short- and long-chain fatty acids. In the last few years, all of the genes encoding the CoA biosynthetic enzymes have been identified and the structures of several proteins in the pathway have been determined.