Dangers of hyperoxia | Critical Care | Full Text - BioMed Central
2021年12月19日 · Oxygen (O2) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O2, i.e. inspiratory O2 concentrations (FIO2) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO2 > 100 mmHg) and, subsequently, hyperoxia (increased tissue O2 concentration), thereby enhancing ROS formation. Here, we review the ...
Hemodynamic effects of acute hyperoxia: systematic review and …
2018年2月25日 · On the other hand, hyperoxic peripheral vasoconstriction may improve circulatory shock, potentially reducing the need for fluid and vasopressor resuscitation [11, 12]. The magnitude of hyperoxia-induced hemodynamic alterations is currently unclear, as is the generalizability of the effects to different types of patients.
Bench-to-bedside review: the effects of hyperoxia during critical ...
2015年12月1日 · Additionally, prolonged hyperoxic exposure alters the microbial flora in the upper airways and further increases the risk of secondary infections and lethality. Notably, these pulmonary effects are often in addition to the primary (e.g., pneumonia) and secondary (e.g., ventilator-induced lung injury) lung injury, which are accompanied by ...
Hyperoxemia and excess oxygen use in early acute respiratory …
2020年3月31日 · Background Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods In this secondary analysis of the LUNG SAFE study, we wished to ...
Effects of hyperoxia on vascular tone in animal models: systematic ...
2018年8月4日 · Increased constriction was seen in vessels 15–25 μm in diameter. Hyperoxic constriction appeared to be directly proportional to oxygen concentration. For ex vivo studies, heterogeneity could not be explained with subgroup analysis. The effect of hyperoxia on vascular tone is substantially higher in vivo than ex vivo.
Impact of hyperoxia on the gut during critical illnesses
2024年3月1日 · In hyperoxic conditions, NF-κB becomes activated through TLR-4 and TNF pathways, leading to the production of inflammatory cytokines, enterocyte death, and the suppression of Nrf2 . Supplementation of N-acetylcysteine, a potent antioxidant, mitigates hyperoxia-induced gut injury by inhibiting ROS production [ 52 ].
Emergency department hyperoxia is associated with increased …
2018年1月18日 · Background Providing supplemental oxygen is fundamental in the management of mechanically ventilated patients. Increasing amounts of data show worse clinical outcomes associated with hyperoxia. However, these previous data in the critically ill have not focused on outcomes associated with brief hyperoxia exposure immediately after endotracheal intubation. Therefore, the objectives of this ...
Hyperoxic acute lung injury and ventilator-induced/associated …
2007年4月19日 · In patients with acute respiratory distress syndrome (ARDS), supportive therapy with mechanical ventilation and oxygen is often life saving. Further acute lung injury however, is an unfortunate consequence of oxygen therapy as well as mechanical injury secondary to ventilator induced/associated lung injury (VI/ALI). In this issue of Critical Care, Li et al. expand on the intra-cellular ...
Hyperoxic damage and the need for optimised oxygenation …
2013年7月25日 · However, oxygen in excess to normal physiology has the potential to disrupt homeostasis and cause adverse effects. In order to establish best practice for oxygen supplementation - a practice deeply ingrained in current medical techniques - clinical outcomes and pathophysiological mechanisms for hyperoxic damage need to be delineated.
Moderate hyperoxic versus near-physiological oxygen targets …
2016年3月10日 · Background The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme perioperative hyperoxia (>400 mmHg). In this study we investigated whether an oxygenation strategy from moderate hyperoxia to a near-physiological oxygen tension reduces myocardial damage and ...