Nude mouse - Wikipedia
A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname.
Nude Mice - The Jackson Laboratory
The mouse is arguably the most widely used mammalian model in biomedical research. Among the various mouse models, nude mice were the first immunocompromised strain to be used in research. Despite advances in the field, nude mice remain an essential player in various studies.
Nude Mice | Charles River
Nude mice were the first immunocompromised mouse strain to be used in cancer research. Our nude mouse models are ideal for cancer studies because they don't reject tumor cells. These strains give insight into multiple forms of immune deficiencies.
Nude Mouse - an overview | ScienceDirect Topics
The nude mouse is an immunocompromised strain, which lacks hair due to a spontaneous mutation in the FOXN1 gene, but also lacks a thymus, resulting in a limited T cell development. From: Translational Immunotherapy of Brain Tumors, 2017
002019 - nude Strain Details - The Jackson Laboratory
Homozygous nude mice show partial defect in B cell development. For a hairless mouse without severe immunodeficiency, we offer mice carrying the hairless allele ( Hr hr ) as Stock No. 017840 .
Nude Mouse - an overview | ScienceDirect Topics
A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells.
Nude Mouse - an overview | ScienceDirect Topics
The first immunodeficient mouse model was the “nude” mouse, a mutant mouse strain that in addition to the lack of a thymus also is hairless (Flanagan, 1966). These mice have functional B cells and natural killer (NK) cells, but no T cells.
CD-1® Nude Mouse | Charles River - Charles River Laboratories
CD-1® Nude mice are immunodeficient in nature and are used in immuno-oncology, tumor and xenograft research.
Establishment of Nude Mice Lacking NK Cells and Their ...
Nude mice were the first immunocompromised mouse strain to be discovered, in 1962, and have been used for various cancer studies (Flanagan, 1966). They show abnormal hair growth and defective development of the thymic epithelium caused by spontaneous deletion in the Foxn1 gene (Nehls et al., 1994).
Swiss Nude Mice | Charles River - Charles River Laboratories
Charles River provides laboratory animal models, including the Swiss Nude Mouse, for use in basic research and nonclinical drug discovery and development.
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