TERT 基因为何如此重要？_肿瘤_区域_机制 - 搜狐
2022年1月14日 · tert 基因启动子上的基因突变赋予肿瘤细胞“长生不老”的特性，让肿瘤细胞能够不受限制地生长。tert 基因的表达可参与乳腺癌，肺癌，甲状腺癌，肝癌及黑色素瘤等肿瘤的发生，并且 tert 基因启动子的突变均与这些肿瘤的发生、发展及预后密切相关。
TERT Gene - GeneCards | TERT Protein | TERT Antibody
2024年12月10日 · TERT (Telomerase Reverse Transcriptase) is a Protein Coding gene. Diseases associated with TERT include Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 1 and Dyskeratosis Congenita, Autosomal Dominant 2. Among its related pathways are MITF-M-dependent gene expression and Chromosome Maintenance.
Telomerase reverse transcriptase - Wikipedia
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.
TERT gene - MedlinePlus
The TERT gene provides instructions for making one component of an enzyme called telomerase. Learn about this gene and related health conditions.
The regulations of telomerase reverse transcriptase (TERT) in cancer
2024年1月26日 · As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in its promoter and phosphorylation respectively...
TERT telomerase reverse transcriptase [ (human)] - National …
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat.
TERT gene: its function and dysregulation in cancer - PubMed
In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined.
TERT—Regulation and Roles in Cancer Formation - PMC
In most human cancers, telomerase is reactivated during carcinogenesis by expression of the catalytic subunit telomerase reverse transcriptase (TERT). TERT plays a key role in cancer formation, ensuring chromosomal stability by maintaining telomere length, and allowing cells to avert senescence.
TERT telomerase reverse transcriptase [ Homo sapiens (human) ]
2024年12月10日 · Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat.
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking …
Telomerase, an RNA-dependent DNA polymerase with telomerase reverse transcriptase (TERT) as the catalytic component, is silent due to the tight repression of the TERT gene in most normal human somatic cells, whereas activated only in small subsets of cells, including stem cells, activated lymphocytes, and other highly proliferative cells.